Search | VHL Search Portal

1.

Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H₂S Production.

Longchamp, Alban; Mirabella, Teodelinda; Arduini, Alessandro; MacArthur, Michael R; Das, Abhirup; Treviño-Villarreal, J Humberto; Hine, Christopher; Ben-Sahra, Issam; Knudsen, Nelson H; Brace, Lear E; Reynolds, Justin; Mejia, Pedro; Tao, Ming; Sharma, Gaurav; Wang, Rui; Corpataux, Jean-Marc; Haefliger, Jacques-Antoine; Ahn, Kyo Han; Lee, Chih-Hao; Manning, Brendan D; Sinclair, David A; Chen, Christopher S; Ozaki, C Keith; Mitchell, James R.

Cell ; 173(1): 117-129.e14, 2018 03 22.

Article in English | MEDLINE | ID: mdl-29570992

2.

AKT/PKB Signaling: Navigating the Network.

Manning, Brendan D; Toker, Alex.

Cell ; 169(3): 381-405, 2017 04 20.

Article in English | MEDLINE | ID: mdl-28431241

3.

Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling.

Brown, Flavian D; Sen, Debattama R; LaFleur, Martin W; Godec, Jernej; Lukacs-Kornek, Veronika; Schildberg, Frank A; Kim, Hye-Jung; Yates, Kathleen B; Ricoult, Stéphane J H; Bi, Kevin; Trombley, Justin D; Kapoor, Varun N; Stanley, Illana A; Cremasco, Viviana; Danial, Nika N; Manning, Brendan D; Sharpe, Arlene H; Haining, W Nicholas; Turley, Shannon J.

Nat Immunol ; 20(12): 1668-1680, 2019 12.

Article in English | MEDLINE | ID: mdl-31636464

4.

CASTORing New Light on Amino Acid Sensing.

Hallett, James E Hughes; Manning, Brendan D.

Cell ; 165(1): 15-17, 2016 Mar 24.

Article in English | MEDLINE | ID: mdl-27015302

5.

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.

Menon, Suchithra; Dibble, Christian C; Talbott, George; Hoxhaj, Gerta; Valvezan, Alexander J; Takahashi, Hidenori; Cantley, Lewis C; Manning, Brendan D.

Cell ; 156(4): 771-85, 2014 Feb 13.

Article in English | MEDLINE | ID: mdl-24529379

6.

S6K1 Regulates GSK3 under Conditions of mTOR-Dependent Feedback Inhibition of Akt.

Zhang, Hui H; Lipovsky, Alex I; Dibble, Christian C; Sahin, Mustafa; Manning, Brendan D.

Mol Cell ; 83(17): 3217, 2023 Sep 07.

Article in English | MEDLINE | ID: mdl-37683612

7.

Insulin signaling: inositol phosphates get into the Akt.

Manning, Brendan D.

Cell ; 143(6): 861-3, 2010 Dec 10.

Article in English | MEDLINE | ID: mdl-21145450

8.

Chewing the fat on tumor cell metabolism.

Yecies, Jessica L; Manning, Brendan D.

Cell ; 140(1): 28-30, 2010 Jan 08.

Article in English | MEDLINE | ID: mdl-20085702

9.

Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans.

Heintz, Caroline; Doktor, Thomas Koed; Lanjuin, Anne; Escoubas, Caroline; Zhang, Yue; Weir, Heather J; Dutta, Sneha; Silva-García, Carlos Giovanni; Bruun, Gitte Hoffmann; Morantte, Ianessa; Hoxhaj, Gerta; Manning, Brendan D; Andresen, Brage S; Mair, William B.

Nature ; 541(7635): 102-106, 2017 01 05.

Article in English | MEDLINE | ID: mdl-27919065

10.

Corrigendum: Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans.

Heintz, Caroline; Doktor, Thomas K; Lanjuin, Anne; Escoubas, Caroline C; Zhang, Yue; Weir, Heather J; Dutta, Sneha; Silva-García, Carlos Giovanni; Bruun, Gitte H; Morantte, Ianessa; Hoxhaj, Gerta; Manning, Brendan D; Andresen, Brage S; Mair, William B.

Nature ; 547(7664): 476, 2017 07 27.

Article in English | MEDLINE | ID: mdl-28700577

11.

ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis.

Liu, Xue-Song; Haines, Jenna E; Mehanna, Elie K; Genet, Matthew D; Ben-Sahra, Issam; Asara, John M; Manning, Brendan D; Yuan, Zhi-Min.

Genes Dev ; 28(17): 1917-28, 2014 Sep 01.

Article in English | MEDLINE | ID: mdl-25184678

12.

Signalling protein protects the heart muscle from pressure-related stress.

Manning, Brendan D.

Nature ; 566(7743): 187-188, 2019 02.

Article in English | MEDLINE | ID: mdl-30737501

13.

Coordinated regulation of protein synthesis and degradation by mTORC1.

Zhang, Yinan; Nicholatos, Justin; Dreier, John R; Ricoult, Stéphane J H; Widenmaier, Scott B; Hotamisligil, Gökhan S; Kwiatkowski, David J; Manning, Brendan D.

Nature ; 513(7518): 440-3, 2014 Sep 18.

Article in English | MEDLINE | ID: mdl-25043031

14.

TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.

Dibble, Christian C; Elis, Winfried; Menon, Suchithra; Qin, Wei; Klekota, Justin; Asara, John M; Finan, Peter M; Kwiatkowski, David J; Murphy, Leon O; Manning, Brendan D.

Mol Cell ; 47(4): 535-46, 2012 Aug 24.

Article in English | MEDLINE | ID: mdl-22795129

15.

Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA).

Housden, Benjamin E; Li, Zhongchi; Kelley, Colleen; Wang, Yuanli; Hu, Yanhui; Valvezan, Alexander J; Manning, Brendan D; Perrimon, Norbert.

Proc Natl Acad Sci U S A ; 114(50): E10755-E10762, 2017 12 12.

Article in English | MEDLINE | ID: mdl-29183982

16.

Activation of a metabolic gene regulatory network downstream of mTOR complex 1.

Düvel, Katrin; Yecies, Jessica L; Menon, Suchithra; Raman, Pichai; Lipovsky, Alex I; Souza, Amanda L; Triantafellow, Ellen; Ma, Qicheng; Gorski, Regina; Cleaver, Stephen; Vander Heiden, Matthew G; MacKeigan, Jeffrey P; Finan, Peter M; Clish, Clary B; Murphy, Leon O; Manning, Brendan D.

Mol Cell ; 39(2): 171-83, 2010 Jul 30.

Article in English | MEDLINE | ID: mdl-20670887

17.

Zhang & Manning reply.

Zhang, Yinan; Manning, Brendan D.

Nature ; 529(7586): E2-3, 2016 Jan 21.

Article in English | MEDLINE | ID: mdl-26791732

18.

Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis.

Ozcan, Umut; Ozcan, Lale; Yilmaz, Erkan; Düvel, Katrin; Sahin, Mustafa; Manning, Brendan D; Hotamisligil, Gökhan S.

Mol Cell ; 29(5): 541-51, 2008 Mar 14.

Article in English | MEDLINE | ID: mdl-18342602

19.

Tuberous sclerosis complex 2 loss increases lysophosphatidylcholine synthesis in lymphangioleiomyomatosis.

Priolo, Carmen; Ricoult, Stéphane J H; Khabibullin, Damir; Filippakis, Harilaos; Yu, Jane; Manning, Brendan D; Clish, Clary; Henske, Elizabeth P.

Am J Respir Cell Mol Biol ; 53(1): 33-41, 2015 Jul.

Article in English | MEDLINE | ID: mdl-25780943

20.

Game of TOR - The Target of Rapamycin Rules Four Kingdoms.

Manning, Brendan D.

N Engl J Med ; 377(13): 1297-9, 2017 Sep 28.

Article in English | MEDLINE | ID: mdl-28874074

VHL Search Portal

Information and Knowledge for Health

Config filters

Your selection (0)

Export format:

Export:

Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H₂S Production.

AKT/PKB Signaling: Navigating the Network.

Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling.

CASTORing New Light on Amino Acid Sensing.

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.

S6K1 Regulates GSK3 under Conditions of mTOR-Dependent Feedback Inhibition of Akt.

Insulin signaling: inositol phosphates get into the Akt.

Chewing the fat on tumor cell metabolism.

Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans.

Corrigendum: Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans.

ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis.

Signalling protein protects the heart muscle from pressure-related stress.

Coordinated regulation of protein synthesis and degradation by mTORC1.

TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.

Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA).

Activation of a metabolic gene regulatory network downstream of mTOR complex 1.

Zhang & Manning reply.

Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis.

Tuberous sclerosis complex 2 loss increases lysophosphatidylcholine synthesis in lymphangioleiomyomatosis.

Game of TOR - The Target of Rapamycin Rules Four Kingdoms.